The second season of Degrassi High premiered on November 5, 1990 with 13 episodes and ended with the first ever feature length film in the Degrassi franchise, Degrassi: School's Out a year after all the episodes had aired.
- L. Dean Ifill as Bronco Davis, the smart, hard-working school president, Lucy's new love interest.
- David Armin-Parcells as Claude Tanner, an 'environmental activist' and goth kid poseur, who is pressured to the point of suicide.
- Darrin Brown as Dwayne Myers, the tough school bully and Joey's nemesis, struggling with the news that he is HIV+.
- Neil Hope as Derek "Wheels" Wheeler, a troubled orphan developing problems with lying, stealing and drinking, plays bass in the band Zit Remedy.
- Stefan Brogren as Archibald "Snake" Simpson, a tall, friendly student making awkward attempts at finding love, plays guitar in the band Zit Remedy.
- Anais Granofsky as Lucy Fernandez, a worldy, popular girl and budding filmmaker.
- Angela Deiseach as Erica Farrell, a loud, boy-crazy girl who has a love/hate relationship with her twin sister.
- Maureen Deiseach as Heather Farrell, a somewhat timid girl with strong morals who has a love/hate relationship with her twin sister.
- Amanda Stepto as Christine "Spike" Nelson, an easy-going, punk-rock girl who is dealing with being an unwed teen mother and trying to find love.
- Cathy Keenan as Liz O' Rourke, an opinionated, punk rock girl haunted by memories of being molested as a child.
- Irene Courakos as Alexa Pappadopolos, a overly dramatic, boy-obsessed girl.
- Michael Carry as Simon Dexter, a cute, dim-witted student and Alexa's boyfriend, famous around school for his budding modeling/acting career.
- Maureen McKay as Michelle Accette, a shy girl from a broken home now struggling to live on her own, Alexa's best friend.
- Dayo Ade as B.L.T. Thomas, an athletic student and talented basketball player with a complicated love life.
- Sara Holmes and Jacy Hunter as Amy Holmes and Alison Hunter, inseparable best friends, stuck up and snobby troublemakers.
- Pat Mastroianni as Joey Jeremiah, a humorous and immature class clown, plays keyboard in the band Zit Remedy.
- Stacie Mistysyn as Caitlin Ryan, a human rights activist and aspiring journalist who discovers her father is cheating on her mother with another woman.
- Kyra Levy as Maya Goldberg, a Jewish girl in a wheelchair, Caitlin's close friend.
- Sara Ballingall as Melanie Brodie, a gawky but open-minded girl always trying to 'fit in'.
- Rebecca Haines as Kathleen Mead, a gossipy girl with a bad attitude and a troubled past.
- Chrissa Erodotou as Diana Economopoulos, a boy-crazy, chain-smoking greek girl raised by her strict older brother.
- Duncan Waugh as Arthur Kobalewscuy, an awkward, newly wealthy outcast struggling with potentially losing his best friend to a 'cool' new crowd.
- Siluck Saysanasy as Yick Yu, a former nerd who has reinvented himself, falling in with a 'cooler' crowd and experimenting with drugs and alcohol.
- John Ioannou as Alex Yankou, the school's biggest nerd, struggling with 'first love'.
- Kirsten Bourne as Tessa Campanelli, an immature, slightly promiscuous girl who is becoming increasingly boy-obsessed.
- Adam David as Mr. Walfish, the 'hip' English teacher, generally seen teaching grade 11.
- John Weir as Mr. Webster, the Scottish science teacher, generally seen teaching grade 10.
- Florence Darnell as Mrs. Perry, the special education teacher.
- Dan Woods as Daniel Raditch, former junior high teacher, now the school vice principal.
- Steve Bedernjak as Clutch, a older, hard drinking, troublemaking student. (Grade 13/OAC)
- Vincent Walsh as Patrick, an Irish punk rocker, Spike's ex-boyfriend. (Grade 12)
- Byrd Dickens as Scott Smith, Kathleen's physically abusive ex-boyfriend. (Grade 12)
- George Chaker and Michelle Johnson-Murray as Nick and Tabi, school bullies, struggling with the fact that their former friend and leader is HIV+. (Grade 11)
- Arlene Lott as Nancy Kramer, the know-it-all school president who keeps herself updated on everything. (Grade 11)
- Keith White as Tim O'Connor, a smart, bookish student, Nancy's best friend, harboring a crush on Liz. (Grade 11)
- Krista Houston as Joanne Rutherford, a preachy, 'bleeding heart' student who has a mother who works with AIDS patients, Claude's only friend. (Grade 11)
- Marsha Ferguson as Cindy, a volleyball player and BLT's new girlfriend. (Grade 11)
- Cameron Graham as Dale, a sexist jock. (Grade 11)
- Andy Chambers as Luke Matthews, a troublemaking student involved in drugs. (Grade 10)
- Christopher Charlesworth as Scooter Webster, a short 'advanced development' geek. (Grade 10)
- Trevor Cummings as Bartholomew Bond, a smart, snobby pipsqueak, Scooter's close friend. (Grade 10)
- Danah-Jean Brown as Trish Skye, a punk rock girl with a mohawk, active in many school activities. (Grade 10)
- Tammy Campbell as Trudi Owens, a punk rock student with a bright red streak in her hair. (Grade 10)
- Annabelle Wough as Dorothy, Arthur's geeky cousin, Tessa's best friend. (Grade 10)
- Ashlee Henricks as Emma Nelson, Spike's daughter.
Main article: Episode Guide
|Season #||Series #||Title||Original Airdate||Production Code|
|1||16||"Bad Blood" Part 1||November 5, 1990||201|
|2||17||"Bad Blood" Part 2||November 12, 1990||202|
|3||18||"Loyalties"||November 19, 1990||203|
|4||19||"A Tangled Web"||November 26, 1990||204|
|5||20||"Body Politics"||December 3, 1990||205|
|6||21||"Crossed Wires"||December 10, 1990||206|
|7||22||"The All-Nighter"||December 17, 1990||207|
|8||23||"Home Sweet Home"||December 24, 1990||208|
|9||24||"Extracurricular Activities"||December 31, 1990||209|
|10||25||"Showtime" Part 1||January 7, 1991||210|
|11||26||"Showtime" Part 2||January 14, 1991||211|
|12||27||"Three's a Crowd"||January 21, 1991||212|
|13||28||"One Last Dance"||January 28, 1991||213|
|14||29||"School's Out"||January 5, 1992||214|