- Archie Simpson was the first and only regular character to appear throughout the entire franchise.
- Mr. Lawrence was the first unseen character.
- Heather Farrell was the first "Heather" on camera.
- Heather Sinclair was the first "Unseen Heather" in the franchise.
- Arthur Kobalewsky was the first character to speak on Degrassi.
- L.D. Delacorte was the first character to have a speech impediment.
- Stephanie Kaye was the first character to dress one way when she left her house, but change into something else at school.
- Stephanie Kaye and Archie Simpson were the first characters to run for president.
- Voula Grivogiannis was the first character to sneak out.
- Yick Yu was the first character to be disorganized.
- Stephanie Kaye was the first character to have severe depression.
- Stephanie Kaye, Erica Farrell, and Heather Farrell were the first characters to drink alcohol.
- Stephanie Kaye was the first character to be drunk at school.
- Kathleen Mead and Melanie Brodie were the first characters to become interested in drugs.
- Joey Jeremiah was the first character to pretend to be a drug dealer.
- Michelle Accette was the first character to become addicted to caffeine pills.
- Caroline Nash was the first character to be sent to rehab.
- Paige Michalchuk was the first character to be high during an interview.
- Peter Stone was the first character to plant drugs in someone's locker.
- Riley Stavros was the first character to become addicted to steroids.
- Katie Matlin was the first character with a pain killer addiction.
- Glen Martin was the first parent to allow their child to smoke marijuana.
- Kathleen Mead was the first character to have (an) alcoholic parent(s).
- Rick Munro was the first character to be abused by their parent.
- Spike Nelson was the first character to be a teen mom.
- Shane McKay was the first character to become a teen father.
- Heather Farrell and Erica Farrell were the first set of twins on Degrassi.
- Declan and Fiona Coyne were the first siblings to kiss.
- Rick Munro was the first character to live with an older sibling rather than his parents.
- Jake Martin and Clare Edwards were the first step-siblings to date each other.
- Archie Simpson was the first character to have a gay older brother.
- Caitlin Ryan was the first character to be confused about their sexuality.
- Marco Del Rossi was the first character to be gay bashed.
- Alex Nuñez was the first character to blackmail someone with their sexuality.
- Glen Simpson was the first homosexual character in the series.
- Alex Nunez was the first character to come out as a lesbian.
- Paige Michalchuk was the first character to come out as bisexual.
- Imogen Moreno was the first character to have an unclear sexuality.
- Adam Torres was the first transgender character on Degrassi.
- He is also the very first scripted transgender character on television, besides guest roles and documentaries.
- Fiona Coyne was the first character to date one of each person from the LGBT community.
- Lucy Fernandez was the first character to shop lift.
- Derek Wheeler was the first character to be adopted.
- Rick Munro was the first character who joined a group because of a girl he liked.
- Christine Nelson was the first character to kiss someone on-screen.
- Erica Farrell was the first character to fear she has mono.
- Erica Farrell was the first character to have tonsilitis.
- Spike Nelson was the first character to face teenaged pregnancy (also the first to keep the child).
- Shane McKay was the first character to leave his girlfriend because she was pregnant.
- Spike Nelson was the first character to be thrown out of school because of her pregnancy.
- Emma Nelson was the first character to go through a pregnancy scare.
- Erica Farrell was the first character to have an abortion.
- Liz O'Rourke was the first character to have been molested as a young child.
- Darryl Armstrong was the first character to be wrongly acused of sexually abusing a student.
- Darcy Edwards was the first character to have a purity ring.
- Christine Nelson and Shane McKay were the first characters to have sex.
- Joey Jeremiah was the first character to have his buttocks shown on screen.
- Dwayne Myers was the first character to test positive for HIV or any other STD.
- Toby Isaacs and J.T. Yorke were the first characters to watch pornography online.
- J.T. Yorke was the first character to use a sex toy.
- Spinner Mason was the first character to have problems controlling his erections.
- Melanie Brodie was the first character to feel self-conscious about her breast-size.
- Jay Hogart was the first character to contract gonorrhea, or any other STI.
- Manny Santos was the first character to reveal herself on camera.
- Devon was the first male-prostitute.
- Alex Nuñez was the first main character to become a stripper.
- Alli Bhandari was the first character to almost commit a sexual act for money.
- Lucy Fernandez was the first character to be a harrased by an authority figure
- Fiona Coyne was the first character to have a "spring fling".
- Stephanie Kaye and Arthur Kobalewsky were the first character to have her parents divorce.
- The Zits were the first band. Making Archie Simpson, Derek Wheeler, and Joey Jeremiah the first characters to create a band.
- Archie Simpson was the first character to say fucking.
- Rick Munro was the first character to repeat a year.
- Claude Tanner was the first character to commit suicide.
- Derek Wheeler was the first main character to be sent to jail.
- Liz O'Rourke and Erica Farrell were the first characters to have the first female fistfight.
- Eli Goldsworthy was the first character to be a hoarder.
- Craig Manning was the first character to be bipolar.
- Ellie Nash was the first character to do self-harm.
- Craig Manning was the first character to attempt suicide and fail.
- Kathleen Mead was the first character to develop an eating disorder.
- Kathleen Mead was the first character to be in an abusive relationship. She was abused by Scott Smith.
- Bianca DeSousa was the first character to be in a forced relationship.
- Claude Tanner was the first character to bring a gun to school.
- Hazel Aden was the first character to be ashamed of her culture.
- Joey Jeremiah was the first character to joyride a car.
- Melanie Brodie was the first character to have a crush on a teacher.
- Paige Michalchuk was the first character to be in a relationship with a teacher.
- Paige Michalchuk was the first character to purposely crash a vehicle.
- Shane McKay was the first character to wind up in a coma.
- Shane McKay was the first character to have brain damage.
- Michelle Accette, Cindy, and B.L.T. Thomas were the first love triangle.
- Sav Bhandari was the first character to have an arranged marriage awaiting his future.
- Paige Michalchuk was the first character to face her abuser in court.
- Rick Munro was the first character with a smoking addiction.
- Chris Sharpe was the first character to be an aspiring DJ and rap artist.
- Sadie Rowland and Dave Turner were the first tall girl-short guy relationship.
- Sadie Rowland was the first girl to be interested in basketball.
- Jane Vaughn was the first character to legally change her name.
- Spinner Mason was the first character to get shot in the shoulder.
- Adam Torres and Dave Turner were the first characters to have their own radio show on Degrassi's airwaves.
- Stephanie Kaye was the first character to be featured on Degrassi's first freeze frame.
- Simon Dexter was Degrassi's first male-model, and the first model in the series.
- Simon Dexter and Alexa Pappadopolos were the first sweethearts to get married right out of high school.
- Fiona Coyne was the first character to design her own clothes.
- Alex Nunez was the first character to take an extra semester voluntarilly.
- Marco Del Rossi was the first character to have a gambling addiction.
- Anya MacPherson was the first female character to go into the army.
- Spinner Mason was the first character to lie about getting into college.
- Darcy Edwards was the first character to move to Kenya, Africa.
- Terri MacGreggor was the first character to transfer schools over her ex-boyfriend's abuse.
- Melanie Brodie was the first character to have braces.
- L.D. Delacorte was the first character to be diagnosed and hospitalized with cancer.
- Anya MacPherson was the first character to be diagnosed with dyslexia.
- Becca was the first diabetic character.
- Derek Wheeler was the first character to run away from home.
- Derek Wheeler was the first character to hitchhike.
- Michelle Accette and B.L.T. Thomas were the first mixed-race couple.
- Michelle Accette was the first character to move out and live on her own.
- Craig Manning was the first character to achieve a record label.
- Joey Jeremiah was the first character that was a (former) bully who was a victim of another bully.
- Yick Yu was the first character to be jealous of a rich best friend.
- Connor DeLaurier was the first character to be diagnosed with Aspergers Syndrome.
- Yick Yu was the first character to be "picked on" by a teacher.
- B.L.T. Thomas was the first character to be a victim of raicism.
- Laura Coyne was the first major character to be put under house arrest.
- Audra Torres was the first parent to go to conferences for children other than their own.
- Wesley Betenkamp was the first of three boys to kiss Clare Edwards in their first episode.
- Tristan Milligan was the first character to have a heart attack.
- L.D.'s father was the first character to suffer from angina.
- Archie Simpson was the first character to find the body of a suicide victim on the school campus.
- B.L.T. Thomas was the first character to not be accepted by their love interest's parents.
- Sean Cameron was the first character to say the commonly used line, "Go to hell".
- Caitlin Ryan was the first character to graduate high school a year early.
- Sav Bhandari and Anya MacPherson were the first couple to break up more than four times.
- Stephanie Kaye was the first character to lie about her age in order to date an older man.
- Sean Cameron was the first character to join the Canadian Armed Forces.
- Archie Simpson was the first character to serenade their love interest.
- Caitlin Ryan was the first character with a passion for journalism.
- Daniel Raditch was the first character to be promoted from teacher to principal.
- Ellie Nash was the first ever goth character introduced to the series.
- Becky Baker was the first character to be sent to a reparative therapy facility.
- Manny Santos was the first charcter to have her own catchphrase..
- Maya Matlin was the first character to struggle coping after their love interest killed themself.
- Caitlin Ryan was the first character to be an activist.
- Chantay Black was the first character to run a school gossip blog.
- Clare Edwards was the first character to have laser eye surgery.
- Damian Hayes and Manny Santos were the first couple to start and break up within the same hour.
- Marco Del Rossi and Ellie Nash were the first "beard couple".
- Darcy Edwards was the first character to attempt suicide twice.
- Daphne Hatzilakos was the first character to emancipate their child.
- Peter Stone was the first character to be emancipated.
- Archie Simpson and Daphne Hatzilakos had the first affair between co-workers.
- Darcy Edwards was the first strict christian introduced to the show.
- Dave Turner was the first character to get someone's urine on him other than his own.
- Emma Nelson was the first character to suffer post traumatic stress disorder.
- Ellie Nash was the first female drummer.
- Emma Nelson was the first character to accidentally burn a building down.
- Paige Michalchuk was the first character to commit arson.
- Caroline Nash was the first alcoholic to suffer a relapse.
- Holly J. Sinclair was the first wealthy character to go through financial issues and become less wealthy.
- Lucas Valieri was the first drop out to be welcomed back as alumni.
- Liam Christopoulos was the first major character to treat someone for cancer.
- Mr. Colby was the first authority figure to harass a student.
- Craig Manning was the first orphan.
- Liberty Van Zandt was the first character to use the line, "You're dead to me."
- Maya Goldberg was the first character whom needed to usage of a wheelchair.
- Emma Nelson was the first character to be in a relationship with a guy whom was younger than her.
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List of First Instances on Degrassi
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