The conflict between Maya Matlin and Esme Song is known as Mesme (Maya/Esme). It began in the sixteenth season of Degrassi.
In #SquadGoals, Maya is shown to be uncomfortable when she sees Esme and Zig flirting.
In #TheseAreMyConfessions, Maya sees Zig and Esme hanging out at the party and tells Grace that she thinks Zig and Esme are hooking up.
In #IRegretNothing, Maya apologizes to Esme for kissing Zig but is not forgiven. When Esme walks to class with Zig, she purposely dumps on Maya, still angry that Maya kissed her boyfriend.
In #Woke, Esme is wondering why Maya is taking a lot of money out at an ATM, and is confused when Maya tells her to take care of Zig for her.
In #ImSleep, Esme is in tears when she sees Maya OD-ing, she lays Maya in prone position, and tells Zig to call 911. She is then shown in the hospital, along with Zig, Grace, Zoë, Miles and Tristan to see if Maya is going to make it or not. She is shown relieved when Katie tells everyone that she is going to make it.
- They have both lost a love one to suicide.
- Maya lost her boyfriend, Campbell Saunders, in season 12.
- Esme's mom killed herself when she was 10 years old.
- They have both dated Zig Novak.
- They both have kissed Miles Hollingsworth, but only Maya dated him.
- They both have been slut-shamed by Tristan Milligan due to them being love interest of Miles Hollingsworth.
- They both have had a conflict with Zoë Rivas.